The DNA Laboratory You Can Trust
As a clinician, you’re always trying to gather as much data as possible to make the right decisions. That’s why you need a strong partnership with a DNA laboratory that specializes in getting you results- quickly! That’s why there’s LifeBrite Laboratory.
We are a full-service medical laboratory that has specific expertise in genetic testing. We provide medical grade DNA tests for various reasons such as:
- Carrier Screening
- Inherited Cancer Screening
- Pharmacogenetics
Whether you work in a primary care practice, an outpatient clinic or a hospital, your clinicians need laboratory results quickly. There simply isn’t room for error or delay. We’re here to make sure you get the results you need as soon as possible. We want to be your DNA lab.
Our technicians thrive on establishing a committed partnership with your medical staff with one goal in mind – putting your patients first. No matter what type of laboratory testing you need, we ensure each sample is given the care necessary to provide accurate and timely results for the treatment of each patient.
As a national reference laboratory, we realize that the care and treatment of your patient depend upon solid lab results. That’s why we work tirelessly to provide the most accurate and reliable DNA results with turnaround times that are leading the industry.
We hire the most seasoned lab techs and use the latest technology and methodology to ensure that your patients get the lab results you need to build effective treatment plans.
Our DNA Lab Services Include
Carrier Testing
Inherited Cancer Screening
Pharmacogenetics
Genetic Testing & Pharmacogenetics
What is Pharmacogenetics?
Pharmacogenetics (Pgx) is a vital component of precision medicine and studies how one’s genetic make-up (genotype) influences their response to drugs (or metabolizer type).
The standard “trial and error” approach to medication selection can fail to identify the best initial treatment, potentially causing unpleasant side effects and increasing time without therapeutic benefits. Alternatively, the pharmacogenetic approach provides valuable guidance on medication selection and dosage, making it possible to determine the right dose, for the right patient, at the right time. The principle of tests-This test uses a custom genotyping assay to detect single nucleotide polymorphisms (SNPs) and copy number variation (CNV) in several drug metabolizing enzyme (DME) genes. Identification of the SNPs and CNVs present in these genes produces a genetic profile for a patient. This genetic profile assists physicians in determining the optimal type and dosage of a given medication that is most effective for a patient. Panel options-Panels are designed to detect SNPs and/or CNVs in the genes that influence a patient’s drug metabolizing phenotype for a given class of medications.
When you need a Pgx lab to help your patient understand his or her sensitivity to certain medications, think of LifeBrite Laboratory. We’ll be there for you.
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Anti-cancer Medications Panel
| Drug Class | Drugs | Gene(s) Tested |
|---|---|---|
| Antifolates | Methotrexate | MTHFR |
| Detoxifying Agents | Rasburicase | G6PD |
| Protein Kinase Inhibitors | Gefitinib, Dabrafenib | CYP2D6, G6PD |
Cardiovascular Medications Panel
| Drug Class | Drugs | Gene(s) Tested |
|---|---|---|
| Angiotensin II Receptor Antagonists | Azilsartan, Irbesartan, Losartan | CYP2C9 |
| Antianginal Agents | Ranolazine | CYP2D6 |
| Antiarrhythmics | Flecainide, Mexiletine Propafenone | CYP2D6 |
| Anticoagulants | Warfarin | VKORC1, CYP2C9 |
| Antiplatelets | Clopidogrel, Prasugrel | CYP2C19 |
| Beta Blockers | Carvedilol, Metoprolol, Nebivolol, Propranolol, Timolol | CYP2D6 |
| Diuretics | Torsemide | CYP2C9 |
| Statins | Atorvastatin, Fluvastatin, Lovastatin, Pitavastatin, Pravastatin, Rosuvastatin, Simvastatin | CYP2C9, CYP3A4, SLCO1B1 |
Diabetes/Gastrointestinal Medications Panel
| Drug Class | Drugs | Gene(s) Tested |
|---|---|---|
| Meglitinides | Repaglinide, Nategliniden | CYP2C9, SLCO1B1 |
| Sulfonylureas | Chlorpropamide, Glimepiride, Glipizide, Glyburide, Tolbutamide | CYP2C9 |
| Antiemetics | Dolasetron, Dronabinol, Metoclopramide, Netupitant-Palonosetron, Ondansetron, Palonosetron | CYP2C9, CYP2D6 |
| Proton Pump Inhibitors | Dexlansoprazole, Esomeprazole, Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole | CYP2C19 |
| Gaucher Disease | Eliglustat | CYP2D6 |
Immunology & Urology Medications Panel
| Drug Class | Drugs | Gene(s) Tested |
|---|---|---|
| Anti-gout Agents | Lesinurad, Pegloticase, Probenecid | CYP2C9, G6PD |
| Immunomodulators | Leflunomide, Tofacitinib | CYP2C19 |
| Cholinergic Agonists | Cevimeline | CYP2D6 |
| Immunosuppressant | Tacrolimus | CYP3A5 |
| Alpha-Blockers for Benign Prostatic | Tamsulosin | CYP2D6 |
| Antispasmodics for Overactive Bladder | Darifenacin, Fesoterodine, Mirabegron, Tolterodine | CYP2D6 |
Infectious Disease Medications Panel
| Drug Class | Drugs | Gene(s) Tested |
|---|---|---|
| Antibiotics | Dapsone, Methylene blue, Nitrofurantoin, Sulfamethoxazole | G6PD |
| Anti-HIV | Efavirenz | CYP2B6 |
| Antifungals | Voriconazole | CYP2C19 |
| Antimalarials | Proguanil, Chloroquine, Primaquine | CYP2C19, G6PD |
Pain Medications Panel
| Drug Class | Drugs | Gene(s) Tested |
|---|---|---|
| Muscle Relaxants | Tizanidine, Carisoprodol | CYP1A2, CYP2C19 |
| Anesthetic | Propofol | CYP2B6 |
| NSAIDs | Celecoxib, Diclofenac, Flurbiprofen, Ibuprofen, Indomethacin, Meloxicam, Piroxicam | CYP2C9 |
| Opioids | Morphine, Methadone, Codeine, Dihydrocodeine, Hydrocodone, Oxycodone, Tramadol3, Fentanyl | COMT, CYP2B6, CYP2D6, OPRM1 |
Psychotropic Medications Panel
| Drug Class | Drugs | Gene(s) Tested |
|---|---|---|
| Antiaddictives | Bupropion, Methadone, Naltrexone | ANKK1, CYP2B6, OPRM1 |
| Anti-ADHD Agents | Dexmethylphenidate, Methylphenidate, Amphetamine, Dextroamphetamine, Lisdexamfetamine, Atomoxetine1, Clonidine | ADRA2A, COMT, CYP2D6 |
| Anticonvulsants | Brivaracetam, Lacosamide, Phenobarbital, Primidone, Zonisamide, Fosphenytoin, Phenytoin | CYP2C19, CYP2C9 |
| Antidementia Agents | Donepezil, Galantamine | CYP2D6 |
| Antidepressants | Amitriptyline, Amoxapine, Bupropion, Citalopram, Clomipramine, Desipramine, Desvenlafaxine, Doxepin, Duloxetine, Escitalopram, Fluoxetine, Fluvoxamine, Imipramine, Maprotiline, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Protriptyline, Sertraline, Trimipramine, Venlafaxine Vortioxetine | ANKK1, CYP2B6, CYP2C19, CYP2D6, HTR2A, SLC6A4 |
| Antipsychotics | Aripiprazole, Brexpiprazole, Chlorpromazine, Clozapine, Fluphenazine, Haloperidol, Iloperidone, Olanzapine, Paliperidone, Perphenazine, Pimozide, Risperidone, Tetrabenazine, Thioridazine | CYP1A2, CYP2D6, HTR2A |
| Benzodiazepines | Clobazam, Diazepam, Lorazepam, Oxazepam | CYP2C19, UGT2B15 |
| Other Neurological Agents | Dextromethorphan, Flibanserin | CYP2C19, CYP2D6 |
| Condition | Gene Tested |
|---|---|
| Antipsychotic-Induced Hyperprolactinemia, tardive dyskinesia and weight gain | ANKK1 |
| Hyperhomocysteinemia | MTHFR |
Carrier Testing
Let LifeBrite Labs assist you with finding the right path for your patients.
Carrier Testing For Genetic Illnesses
Carrier screening is recommended by the American College of Obstetricians and Gynecologists
Carrier screening is a genetic test that looks to see if an individual is a carrier for pathogenic, or
Recessive conditions can remain “hidden” in families for generations
For a recessive condition to manifest, a child must inherit two pathogenic variants, one from each parent. Many of these conditions are incredibly debilitating, requiring lifelong care or causing death early in infancy or childhood. By testing to see if one or both parents carry hidden recessive variants, a couple can make proactive choices in family planning.
Dominant conditions manifest with only one pathogenic variant
Only one copy of a dominant allele is needed for a person to be affected by an autosomal dominant disorder. Hereditary breast and ovarian cancer syndrome is a type of dominant disorder that can be passed down from either parent and affects both male and female children.
Carrier screening is most powerful when done before pregnancy
One major benefit of carrier screening is that it provides couples with time to consider a full range of reproductive options. This test should only be considered after a thorough evaluation of the benefits and risks associated with carrier screening. Because there may be difficult choices to consider after receiving test results, we strongly recommend potential parents speak with a genetic counselor or genetic specialist before making any changes in reproductive plans.
Panel Options:
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Carrier Screening Panel
| Alpha Thalassemia | HBA2 |  |
|---|---|---|
| Beta Thalassemia | HBB | |
| Bloom Syndrome | BLM | |
| Canavan Disease | ASPA | |
| Familial Dysautonomia | IKBKAP | |
| Familial Mediterranean Fever | MEFV | |
| Fanconi Anemia: Type C | FANCC | |
| Gaucher Disease | GBA | |
| Glycogen Storage Disease: Type IA | G6PC | |
| Hemochromatosis | HFE | |
| Hereditary Inclusion Body Myopathies | GNE | |
| Mucolipidosis: Type IV | MCOLN1 | |
| Niemann-Pick Disease: Type A (ASM deficiency) | SMPD1 | |
| Sickle-Cell Anemia | HBB | |
| Tay-Sachs Disease | HEXA | |
Ashkenazi Jewish Carrier Screening Panel
| 3-Phosphoglycerate Dehydrogenase Deficiency | PHGDH | |
|---|---|---|
| Abetalipoproteinemia | MTTP | |
| Arthrogryposis, Mental Retardation, & Seizures | SLC35A3 | |
| Bardet-Biedl Syndrome: BBS2 Related | BBS2 | |
| Bloom Syndrome | BLM | |
| Canavan Disease | ASPA | |
| Carnitine Palmitoyltransferase II Deficiency | CPT2 | |
| Congenital Disorder of Glycosylation: Type 1A: PMM2 Related | PMM2 | |
| Dihydrolipoamide Dehydrogenase Deficiency (DLD) | DLD | |
| Familial Dysautonomia | IKBKAP | |
| Familial Hyperinsulinism: Type 1: ABCC8 Related | ABCC8 | |
| Fanconi Anemia: Type C | FANCC | |
| Galactosemia | GALT | |
| Gaucher Disease | GBA | |
| Glycogen Storage Disease: Type IA | G6PC | |
| Hereditary Breast and Ovarian Cancer Syndrome | BRCA1 | |
| Hereditary Breast and Ovarian Cancer Syndrome | BRCA2 | |
| Joubert Syndrome | TMEM216 | |
| Maple Syrup Urine Disease: Type 1B | BCKDHB | |
| Mucolipidosis: Type IV | MCOLN1 | |
| Multiple Sulfatase Deficiency | SUMF1 | |
| Nemaline Myopathy: NEB Related | NEB | |
| Niemann-Pick Disease: Type A (ASM deficiency) | SMPD1 | |
| Tay-Sachs Disease | HEXA | |
| Tyrosinemia: Type I | FAH | |
| Usher Syndrome: Type 1F | PCDH15 & CLRN1 | |
Cystic Fibrosis Panel
| Cystic Fibrosis | CFTR | |
|---|
Inherited Cancer Genetics
Approximately 5-10% of cancers are due to inherited, pathogenic mutations.
Genetic Testing For Cancer
Hereditary cancer syndromes are inherited disorders which increase an individual’s risk of developing one or several types of cancer. Genetic testing for inherited cancer involves sequencing specific genes to determine if any pathogenic, or disease-causing, genetic variations are present. As part of a complete risk assessment, results from this kind of genetic test can help further define an individual’s inherited genetic risk towards several types of hereditary cancer syndromes.
A hereditary cancer risk assessment should be performed before ordering this kind of genetic test.
Genetic testing is a powerful tool for detecting pathogenic variants associated with an increased risk for developing hereditary cancer. However, this testing is not the best option for everyone and has limited utility for those without a family history indicative of hereditary or familial cancer. To identify patients that will benefit the most from this test, a personal and family history of cancer must be performed prior to testing.
Lifebrite offers the following Heredity Cancer Panels:
Panels are designed to detect gDNA from the following microorganisms and/or viruses:
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LBL ICGx-Female Reproductive Tract Cancers Panel
| Gene | GHR | OMIM |
|---|---|---|
| BRCA1 | |
|
| BRCA2 | |
|
| BRIP1 | |
|
| EPCAM | |
|
| MLH1 | |
|
| MSH2 | |
|
| MSH6 | |
|
| PMS2 | |
|
| RAD51C | |
|
| RAD51D | |
|
| STK11 | |
|
LBL ICGx-Breast Cancer Panel
| Gene | GHR | OMIM |
|---|---|---|
| ATM | |
|
| BARD1 | |
|
| BRCA1 | |
|
| BRCA2 | |
|
| BRIP1 | |
|
| CDH1 | |
|
| CHEK2 | |
|
| MRE11A | |
|
| MUTYH | |
|
| NBN | |
|
| NF1 | |
|
| PALB2 | |
|
| PTEN | |
|
| RAD50 | |
|
| RAD51C | |
|
| STK11 | |
|
| TP53 | |
|
LBL ICGx-Prostate Cancer Panel
| Gene | GHR | OMIM |
|---|---|---|
| BRCA1 | |
|
| BRCA2 | |
|
| CHEK2 | |
|
| ELAC2 | |
|
| NBN | |
|
| TP53 | |
|
LBL ICGx-Pancreatic Cancer Panel
| Gene | GHR | OMIM |
|---|---|---|
| APC | |
|
| BRCA1 | |
|
| BRCA2 | |
|
| CDKN2A | |
|
| EPCAM | |
|
| MEN1 | |
|
| MLH1 | |
|
| MSH2 | |
|
| MSH6 | |
|
| PALLD | |
|
| PMS2 | |
|
| STK11 | |
|
| TP53 | |
|
LBL ICGx-Gastric Cancer Panel
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LBL ICGx-Melanoma Panel
| Gene | GHR | OMIM |
|---|---|---|
| CDK4 | |
|
| CDKN2A | |
|
LBL ICGx-Lung Cancer Panel
| Gene | GHR | OMIM |
|---|---|---|
| STK11 | |
|
| TP53 | |
|
LBL ICGx-Renal Cancer Panel
| Gene | GHR | OMIM |
|---|---|---|
| APC | |
|
| EPCAM | |
|
| MET | |
|
| MLH1 | |
|
| MSH2 | |
|
| MSH6 | |
|
| MUTYH | |
|
| PMS2 | |
|
| PTEN | |
|
| TP53 | |
|
| VHL | |
|
LBL ICGx-Tumor Syndromes Panel
| Gene | GHR | OMIM |
|---|---|---|
| FANCC | |
|
| HRAS | |
|
| PTCH1 | |
|
| RET | |
|
LBL ICGx-Comprehensive Hereditary Cancer Panel
| Gene | GHR | OMIM |
|---|---|---|
| APC | |
|
| ATM | |
|
| BARD1 | |
|
| BMPR1A | |
|
| BRCA1 | |
|
| BRCA2 | |
|
| BRIP1 | |
|
| CDH1 | |
|
| CDK4 | |
|
| CDKN2A | |
|
| CHEK2 | |
|
| ELAC2 | |
|
| EPCAM | |
|
| FANCC | |
|
| HRAS | |
|
| MEN1 | |
|
| MET | |
|
| MLH1 | |
|
| MRE11A | |
|
| MSH2 | |
|
| MSH6 | |
|
| MUTYH | |
|
| NBN | |
|
| NF1 | |
|
| PALB2 | |
|
| PALLD | |
|
| PMS2 | |
|
| PTCH1 | |
|
| PTEN | |
|
| RAD50 | |
|
| RAD51 | |
|
| RAD51C | |
|
| RAD51D | |
|
| RET | |
|
| SMAD4 | |
|
| STK11 | |
|
| TP53 | |
|
| VHL | |
|
The DNA Laboratory That Partners With Clinicians
We pride ourselves in our ability to deliver high quality, accurate results in a timely manner. Aside from providing genetic testing results with quality exceeding industry standard, we work with health care professionals to implement cost-effective medication monitoring solutions, drug testing and more. As a result, our medical laboratory has received plenty of accolades for two years in a row.
LifeBrite Laboratories is a customer-centered, accredited genetic testing laboratory committed to delivering results you can trust.
Genetic Testing
We provide a variety of medical genetic testing that you can offer at your clinical practice. Let LifeBrite Laboratories give you the results your patients need to make informed decisions.
Carrier Screening Helps With Family Planning
Carrier screening is a genetic test that looks to see if an individual is a carrier for pathogenic, or disease-causing, genetic variants. This type of test is valuable for couples who want to know their risks for having a child with specific genetic conditions. Carrier screening can look for recessive and autosomal dominant conditions.
Recessive conditions can remain “hidden” in families for generations
For a recessive condition to manifest, a child must inherit two pathogenic variants, one from each parent. Many of these conditions are incredibly debilitating, requiring lifelong care or causing death early in infancy or childhood. By testing to see if one or both parents carry hidden recessive variants, a couple can make proactive choices in family planning.
Dominant conditions manifest with only one pathogenic variant
Only one copy of a dominant allele is needed for a person to be affected by an autosomal dominant disorder. Hereditary breast and ovarian cancer syndrome is a type of dominant disorder that can be passed down from either parent and affects both male and female children.
Carrier screening is most powerful when done before pregnancy.
One major benefit of carrier screening is that it provides couples with time to consider a full range of reproductive options. This test should only be considered after a thorough evaluation of the benefits and risks associated with carrier screening. Because there may be difficult choices to consider after receiving test results, we strongly recommend potential parents speak with a genetic counselor or genetic specialist before making any changes in reproductive plans.
Our Screening Services Include
Ashkenazi Jewish Carrier Screening Panel
General Carrier Screening Panel
Cystic Fibrosis Carrier Screening
Our Promise
We are committed to providing superior customer service. We promise to exceed your expectations by delivering unparalleled value to your organization.
Our Clients
LifeBrite Labs provides medical laboratory services for clinical practices and medical facilities throughout the United States. We work with many different treatment facilities, outpatient clinics, large medical practices and more across New York. We have clients in New York City, Buffalo,Rochester, Yonkers, Syracuse and Albany. Contact us and let’s talk about what we can do for you. Click here to learn more about Med Labs in New York.
PAIN MANAGEMENT
Our lab serves as a medication compliance partner to ensure both physicians and their patients are protected.
WORKERS’ COMP
LifeBrite provides test results to support clinical decision-making and reduce
OB/GYN
Medication misuse and substance abuse during pregnancy can have detrimental health implications for expecting mothers and newborns.
MEDICATION RECONCILIATION
LifeBrite utilizes a proprietary panel developed in-house to help physicians reconcile the medications of their polypharmacy patients who otherwise could be at an increased risk for Adverse Drug events (ADRs).
ADDICTION CLINICS
LifeBrite supports your organization so you can focus on effectively treating your patients.
PRIMARY CARE
Physicians say that prescription drug abuse is a moderate or big problem in their communities. Our medical lab is your medication compliance partner.
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A Hospital, Laboratory, Research & Development Company
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We Service National and Regional Locations | United States of America