Inherited Cancer Genetics

Proactive genetic testing for inherited cancer syndromes enables a preventative approach that can facilitate life-changing interventions

Approximately 5-10% of cancers are due to inherited, pathogenic mutations.

Hereditary cancer syndromes are inherited disorders which increase an individual’s risk of developing one or several types of cancer. Genetic testing for inherited cancer involves sequencing specific genes to determine if any pathogenic, or disease-causing, genetic variations are present. As part of a complete risk assessment, results from this kind of genetic test can help further define an individual’s inherited genetic risk towards several types of hereditary cancer syndromes.

A hereditary cancer risk assessment should be performed before ordering this kind of test.

Genetic testing is a powerful tool for detecting pathogenic variants associated with an increased risk for developing a hereditary cancer. However, this testing is not the best option for everyone, and has limited utility for those without a family history indicative of hereditary or familial cancer. To identify patients that will benefit the most from this test, a personal and family history of cancer must be performed prior to testing.

LBL ICGx-Female Reproductive Tract Cancers Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
BRCA1
BRCA2
BRIP1
EPCAM
MLH1
MSH2
MSH6
PMS2
RAD51C
RAD51D
STK11

Uterine/Endometrial

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
EPCAM
MLH1
MSH2
MSH6
PMS2

LBL ICGx-Breast Cancer Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
ATM
BARD1
BRCA1
BRCA2
BRIP1
CDH1
CHEK2
MRE11A 
MUTYH
NBN
NF1
PALB2
PTEN
RAD50  
RAD51C
STK11
TP53

LBL ICGx-Prostate Cancer Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
BRCA1
BRCA2
CHEK2
ELAC2
NBN
TP53

LBL ICGx-Pancreatic Cancer Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
APC
BRCA1
BRCA2
CDKN2A
EPCAM
MEN1
MLH1
MSH2
MSH6
PALLD
PMS2
STK11
TP53

LBL ICGx-Gastric Cancer Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
APC
BMPR1A
CDH1
EPCAM
FANCC
MLH1
MSH2
MSH6
PMS2
SMAD4
STK11

LBL ICGx-Melanoma Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
CDK4
CDKN2A

LBL ICGx-Lung Cancer Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
STK11
TP53

LBL ICGx-Renal Cancer Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
APC
EPCAM
MET
MLH1
MSH2
MSH6
MUTYH
PMS2
PTEN
TP53
VHL

LBL ICGx-Tumor Syndromes Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
FANCC
HRAS
PTCH1
RET

LBL ICGx-Comprehensive Hereditary Cancer Panel

GeneGHR
(Physicians/Patients)
OMIM
(Researchers/Physicians)
APC
ATM
BARD1
BMPR1A
BRCA1
BRCA2
BRIP1
CDH1
CDK4
CDKN2A
CHEK2
ELAC2
EPCAM
FANCC
HRAS
MEN1
MET
MLH1
MRE11A 
MSH2
MSH6
MUTYH
NBN
NF1
PALB2
PALLD
PMS2
PTCH1
PTEN
RAD50  
RAD51
RAD51C
RAD51D
RET
SMAD4
STK11
TP53
VHL