DNA Laboratories For Washington

The clinical laboratory putting your patients first

As a national reference laboratory, we’re here to help clinicians get the right results – on time, every timeWe deliver accurate results with industry-leading turnaround times.

The DNA Laboratory You Can Trust

As a clinician, you’re always trying to gather as much data as possible to make the right decisions. That’s why you need a strong partnership with a DNA laboratory that specializes in getting you results- quickly! That’s why there’s LifeBrite Laboratory.

We are a full-service medical laboratory that has specific expertise in genetic testing. We provide medical grade DNA tests for various reasons such as:

  • Carrier Screening
  • Inherited Cancer Screening
  • Pharmacogenetics

Whether you work in a primary care practice, an outpatient clinic or a hospital, your clinicians need laboratory results quickly. There simply isn’t room for error or delay. We’re here to make sure you get the results you need as soon as possible. We want to be your DNA lab.

Our technicians thrive on establishing a committed partnership with your medical staff with one goal in mind – putting your patients first. No matter what type of laboratory testing you need, we ensure each sample is given the care necessary to provide accurate and timely results for the treatment of each patient.

 As a national reference laboratory, we realize that the care and treatment of your patient depend upon solid lab results. That’s why we work tirelessly to provide the most accurate and reliable DNA results with turnaround times that are leading the industry.

We hire the most seasoned lab techs and use the latest technology and methodology to ensure that your patients get the lab results you need to build effective treatment plans.

Our DNA Lab Services Include

Carrier Testing

Inherited Cancer Screening

Pharmacogenetics

Genetic Testing & Pharmacogenetics

 

What is Pharmacogenetics?

Pharmacogenetics (Pgx) is a vital component of precision medicine and studies how one’s genetic make-up (genotype) influences their response to drugs (or metabolizer type).

The standard “trial and error” approach to medication selection can fail to identify the best initial treatment, potentially causing unpleasant side effects and increasing time without therapeutic benefits. Alternatively, the pharmacogenetic approach provides valuable guidance on medication selection and dosage, making it possible to determine the right dose, for the right patient, at the right time. The principle of tests-This test uses a custom genotyping assay to detect single nucleotide polymorphisms (SNPs) and copy number variation (CNV) in several drug metabolizing enzyme (DME) genes. Identification of the SNPs and CNVs present in these genes produces a genetic profile for a patient. This genetic profile assists physicians in determining the optimal type and dosage of a given medication that is most effective for a patient. Panel options-Panels are designed to detect SNPs and/or CNVs in the genes that influence a patient’s drug metabolizing phenotype for a given class of medications.

When you need a Pgx lab to help your patient understand his or her sensitivity to certain medications, think of LifeBrite Laboratory. We’ll be there for you. 

invisible

this is an invisible accordion item

Anti-cancer Medications Panel

Drug Class Drugs Gene(s) Tested
Antifolates Methotrexate MTHFR
Detoxifying Agents Rasburicase G6PD
Protein Kinase Inhibitors Gefitinib, Dabrafenib CYP2D6, G6PD

Cardiovascular Medications Panel

Drug Class Drugs Gene(s) Tested
Angiotensin II Receptor Antagonists Azilsartan, Irbesartan, Losartan CYP2C9
Antianginal Agents Ranolazine CYP2D6
Antiarrhythmics Flecainide, Mexiletine Propafenone CYP2D6
Anticoagulants Warfarin VKORC1, CYP2C9
Antiplatelets Clopidogrel, Prasugrel CYP2C19
Beta Blockers Carvedilol, Metoprolol, Nebivolol, Propranolol, Timolol CYP2D6
Diuretics Torsemide CYP2C9
Statins Atorvastatin, Fluvastatin, Lovastatin, Pitavastatin, Pravastatin, Rosuvastatin, Simvastatin CYP2C9, CYP3A4, SLCO1B1

Diabetes/Gastrointestinal Medications Panel

Drug Class Drugs Gene(s) Tested
Meglitinides Repaglinide, Nategliniden CYP2C9, SLCO1B1
Sulfonylureas Chlorpropamide, Glimepiride, Glipizide, Glyburide, Tolbutamide CYP2C9
Antiemetics Dolasetron, Dronabinol, Metoclopramide, Netupitant-Palonosetron, Ondansetron, Palonosetron CYP2C9, CYP2D6
Proton Pump Inhibitors Dexlansoprazole, Esomeprazole, Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole CYP2C19
Gaucher Disease Eliglustat CYP2D6

Immunology & Urology Medications Panel

Drug Class Drugs Gene(s) Tested
Anti-gout Agents Lesinurad, Pegloticase, Probenecid CYP2C9, G6PD
Immunomodulators Leflunomide, Tofacitinib CYP2C19
Cholinergic Agonists Cevimeline CYP2D6
Immunosuppressant Tacrolimus CYP3A5
Alpha-Blockers for Benign Prostatic Tamsulosin CYP2D6
Antispasmodics for Overactive Bladder Darifenacin, Fesoterodine, Mirabegron, Tolterodine CYP2D6

Infectious Disease Medications Panel

Drug Class Drugs Gene(s) Tested
Antibiotics Dapsone, Methylene blue, Nitrofurantoin, Sulfamethoxazole G6PD
Anti-HIV Efavirenz CYP2B6
Antifungals Voriconazole CYP2C19
Antimalarials Proguanil, Chloroquine, Primaquine CYP2C19, G6PD

Pain Medications Panel

Drug Class Drugs Gene(s) Tested
Muscle Relaxants Tizanidine, Carisoprodol CYP1A2, CYP2C19
Anesthetic Propofol CYP2B6
NSAIDs Celecoxib, Diclofenac, Flurbiprofen, Ibuprofen, Indomethacin, Meloxicam, Piroxicam CYP2C9
Opioids Morphine, Methadone, Codeine, Dihydrocodeine, Hydrocodone, Oxycodone, Tramadol3, Fentanyl COMT, CYP2B6, CYP2D6, OPRM1

Psychotropic Medications Panel

Drug Class Drugs Gene(s) Tested
Antiaddictives Bupropion, Methadone, Naltrexone ANKK1, CYP2B6, OPRM1
Anti-ADHD Agents Dexmethylphenidate, Methylphenidate, Amphetamine, Dextroamphetamine, Lisdexamfetamine, Atomoxetine1, Clonidine ADRA2A, COMT, CYP2D6
Anticonvulsants Brivaracetam, Lacosamide, Phenobarbital, Primidone, Zonisamide, Fosphenytoin, Phenytoin CYP2C19, CYP2C9
Antidementia Agents Donepezil, Galantamine CYP2D6
Antidepressants Amitriptyline, Amoxapine, Bupropion, Citalopram, Clomipramine, Desipramine, Desvenlafaxine, Doxepin, Duloxetine, Escitalopram, Fluoxetine, Fluvoxamine, Imipramine, Maprotiline, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Protriptyline, Sertraline, Trimipramine, Venlafaxine Vortioxetine ANKK1, CYP2B6, CYP2C19, CYP2D6, HTR2A, SLC6A4
Antipsychotics Aripiprazole, Brexpiprazole, Chlorpromazine, Clozapine, Fluphenazine, Haloperidol, Iloperidone, Olanzapine, Paliperidone, Perphenazine, Pimozide, Risperidone, Tetrabenazine, Thioridazine CYP1A2, CYP2D6, HTR2A
Benzodiazepines Clobazam, Diazepam, Lorazepam, Oxazepam CYP2C19, UGT2B15
Other Neurological Agents Dextromethorphan, Flibanserin CYP2C19, CYP2D6
Condition Gene Tested
Antipsychotic-Induced Hyperprolactinemia, tardive dyskinesia and weight gain ANKK1
Hyperhomocysteinemia MTHFR

Carrier Testing

Let LifeBrite Labs assist you with finding the right path for your patients. 

Carrier Testing For Genetic Illnesses

 

Carrier screening is recommended by the American College of Obstetricians and Gynecologists

Carrier screening is a genetic test that looks to see if an individual is a carrier for pathogenic, or disease-causing, genetic variants. This type of test is valuable for couples who want to know their risks for having a child with specific genetic conditions. Carrier screening can look for recessive and autosomal dominant conditions.

Recessive conditions can remain “hidden” in families for generations

For a recessive condition to manifest, a child must inherit two pathogenic variants, one from each parent. Many of these conditions are incredibly debilitating, requiring lifelong care or causing death early in infancy or childhood. By testing to see if one or both parents carry hidden recessive variants, a couple can make proactive choices in family planning.

Dominant conditions manifest with only one pathogenic variant

Only one copy of a dominant allele is needed for a person to be affected by an autosomal dominant disorder. Hereditary breast and ovarian cancer syndrome is a type of dominant disorder that can be passed down from either parent and affects both male and female children.

Carrier screening is most powerful when done before pregnancy

One major benefit of carrier screening is that it provides couples with time to consider a full range of reproductive options. This test should only be considered after a thorough evaluation of the benefits and risks associated with carrier screening. Because there may be difficult choices to consider after receiving test results, we strongly recommend potential parents speak with a genetic counselor or genetic specialist before making any changes in reproductive plans.

Panel Options:

invisible

this is an invisible accordion item

Carrier Screening Panel

Alpha Thalassemia HBA2
Beta Thalassemia HBB
Bloom Syndrome BLM
Canavan Disease ASPA
Familial Dysautonomia IKBKAP
Familial Mediterranean Fever MEFV
Fanconi Anemia: Type C FANCC
Gaucher Disease GBA
Glycogen Storage Disease: Type IA G6PC
Hemochromatosis HFE
Hereditary Inclusion Body Myopathies GNE
Mucolipidosis: Type IV MCOLN1
Niemann-Pick Disease: Type A (ASM deficiency) SMPD1
Sickle-Cell Anemia HBB
Tay-Sachs Disease HEXA

Ashkenazi Jewish Carrier Screening Panel

3-Phosphoglycerate Dehydrogenase Deficiency PHGDH
Abetalipoproteinemia MTTP
Arthrogryposis, Mental Retardation, & Seizures SLC35A3
Bardet-Biedl Syndrome: BBS2 Related BBS2
Bloom Syndrome BLM
Canavan Disease ASPA
Carnitine Palmitoyltransferase II Deficiency CPT2
Congenital Disorder of Glycosylation: Type 1A: PMM2 Related PMM2
Dihydrolipoamide Dehydrogenase Deficiency (DLD) DLD
Familial Dysautonomia IKBKAP
Familial Hyperinsulinism: Type 1: ABCC8 Related ABCC8
Fanconi Anemia: Type C FANCC
Galactosemia GALT
Gaucher Disease GBA
Glycogen Storage Disease: Type IA G6PC
Hereditary Breast and Ovarian Cancer Syndrome BRCA1
Hereditary Breast and Ovarian Cancer Syndrome BRCA2
Joubert Syndrome TMEM216
Maple Syrup Urine Disease: Type 1B BCKDHB
Mucolipidosis: Type IV MCOLN1
Multiple Sulfatase Deficiency SUMF1
Nemaline Myopathy: NEB Related NEB
Niemann-Pick Disease: Type A (ASM deficiency) SMPD1
Tay-Sachs Disease HEXA
Tyrosinemia: Type I FAH
Usher Syndrome: Type 1F PCDH15 & CLRN1

Cystic Fibrosis Panel

Cystic Fibrosis CFTR

Inherited Cancer Genetics

Approximately 5-10% of cancers are due to inherited, pathogenic mutations.

Genetic Testing For Cancer

 

Hereditary cancer syndromes are inherited disorders which increase an individual’s risk of developing one or several types of cancer. Genetic testing for inherited cancer involves sequencing specific genes to determine if any pathogenic, or disease-causing, genetic variations are present. As part of a complete risk assessment, results from this kind of genetic test can help further define an individual’s inherited genetic risk towards several types of hereditary cancer syndromes.

A hereditary cancer risk assessment should be performed before ordering this kind of genetic test.

Genetic testing is a powerful tool for detecting pathogenic variants associated with an increased risk for developing hereditary cancer. However, this testing is not the best option for everyone and has limited utility for those without a family history indicative of hereditary or familial cancer. To identify patients that will benefit the most from this test, a personal and family history of cancer must be performed prior to testing.

Lifebrite offers the following Heredity Cancer Panels:

Panels are designed to detect gDNA from the following microorganisms and/or viruses:

invisible

this item is invisible to keep the accordion closed by default

LBL ICGx-Female Reproductive Tract Cancers Panel

Gene GHR OMIM
BRCA1
BRCA2
BRIP1
EPCAM
MLH1
MSH2
MSH6
PMS2
RAD51C
RAD51D
STK11

LBL ICGx-Breast Cancer Panel

Gene GHR OMIM
ATM
BARD1
BRCA1
BRCA2
BRIP1
CDH1
CHEK2
MRE11A
MUTYH
NBN
NF1
PALB2
PTEN
RAD50
RAD51C
STK11
TP53

LBL ICGx-Prostate Cancer Panel

Gene GHR OMIM
BRCA1
BRCA2
CHEK2
ELAC2
NBN
TP53

LBL ICGx-Pancreatic Cancer Panel

Gene GHR OMIM
APC
BRCA1
BRCA2
CDKN2A
EPCAM
MEN1
MLH1
MSH2
MSH6
PALLD
PMS2
STK11
TP53

LBL ICGx-Gastric Cancer Panel

Your content goes here. Edit or remove this text inline or in the module Content settings. You can also style every aspect of this content in the module Design settings and even apply custom CSS to this text in the module Advanced settings.

LBL ICGx-Melanoma Panel

Gene GHR OMIM
CDK4
CDKN2A

LBL ICGx-Lung Cancer Panel

Gene GHR OMIM
STK11
TP53

LBL ICGx-Renal Cancer Panel

Gene GHR OMIM
APC
EPCAM
MET
MLH1
MSH2
MSH6
MUTYH
PMS2
PTEN
TP53
VHL

LBL ICGx-Tumor Syndromes Panel

Gene GHR OMIM
FANCC
HRAS
PTCH1
RET

LBL ICGx-Comprehensive Hereditary Cancer Panel

Gene GHR OMIM
APC
ATM
BARD1
BMPR1A
BRCA1
BRCA2
BRIP1
CDH1
CDK4
CDKN2A
CHEK2
ELAC2
EPCAM
FANCC
HRAS
MEN1
MET
MLH1
MRE11A
MSH2
MSH6
MUTYH
NBN
NF1
PALB2
PALLD
PMS2
PTCH1
PTEN
RAD50
RAD51
RAD51C
RAD51D
RET
SMAD4
STK11
TP53
VHL

The DNA Laboratory That Partners With Clinicians

We pride ourselves in our ability to deliver high quality, accurate results in a timely manner. Aside from providing genetic testing results with quality exceeding industry standard, we work with health care professionals to implement cost-effective medication monitoring solutions, drug testing and more. As a result, our medical laboratory has received plenty of accolades for two years in a row.

LifeBrite Laboratories is a customer-centered, accredited genetic testing laboratory committed to delivering results you can trust.

Genetic Testing

We provide a variety of medical genetic testing that you can offer at your clinical practice. Let LifeBrite Laboratories give you the results your patients need to make informed decisions.

Carrier Screening Helps With Family Planning

Carrier screening is a genetic test that looks to see if an individual is a carrier for pathogenic, or disease-causing, genetic variants. This type of test is valuable for couples who want to know their risks for having a child with specific genetic conditions. Carrier screening can look for recessive and autosomal dominant conditions.

Recessive conditions can remain “hidden” in families for generations

For a recessive condition to manifest, a child must inherit two pathogenic variants, one from each parent. Many of these conditions are incredibly debilitating, requiring lifelong care or causing death early in infancy or childhood. By testing to see if one or both parents carry hidden recessive variants, a couple can make proactive choices in family planning.

Dominant conditions manifest with only one pathogenic variant

Only one copy of a dominant allele is needed for a person to be affected by an autosomal dominant disorder. Hereditary breast and ovarian cancer syndrome is a type of dominant disorder that can be passed down from either parent and affects both male and female children.

Carrier screening is most powerful when done before pregnancy.

One major benefit of carrier screening is that it provides couples with time to consider a full range of reproductive options. This test should only be considered after a thorough evaluation of the benefits and risks associated with carrier screening. Because there may be difficult choices to consider after receiving test results, we strongly recommend potential parents speak with a genetic counselor or genetic specialist before making any changes in reproductive plans.

Our Screening Services Include

Ashkenazi Jewish Carrier Screening Panel

General Carrier Screening Panel

Cystic Fibrosis Carrier Screening

Our Promise

We are committed to providing superior customer service. We promise to exceed your expectations by delivering unparalleled value to your organization.

 

Our Clients

LifeBrite Labs provides medical laboratory services for clinical practices and medical facilities throughout the United States. We work with many different treatment facilities, outpatient clinics, large medical practices and more across Washington. We have clients in Seattle, Spokane, Tacoma, Vancouver and Bellevue. Contact us and let’s talk about what we can do for you. Click here to learn more about the best med labs in Washington.

PAIN MANAGEMENT

Our lab serves as a medication compliance partner to ensure both physicians and their patients are protected.

WORKERS’ COMP

LifeBrite provides test results to support clinical decision-making and reduce medication related risk in injured workers.

OB/GYN

Medication misuse and substance abuse during pregnancy can have detrimental health implications for expecting mothers and newborns.

MEDICATION RECONCILIATION

LifeBrite utilizes a proprietary panel developed in-house to help physicians reconcile the medications of their polypharmacy patients who otherwise could be at an increased risk for Adverse Drug events (ADRs).

ADDICTION CLINICS

LifeBrite supports your organization so you can focus on effectively treating your patients. 

PRIMARY CARE

Physicians say that prescription drug abuse is a moderate or big problem in their communities. Our medical lab is your medication compliance partner.

Sitemap

About
Testing Services
Why Choose Us
Technology
News
Contact Us

Contact Us

© 2019 LifeBrite Laboratories.
A Hospital, Laboratory, Research & Development Company