Pharmacogenomics

Reduce trial and error in medicine with LifeBrite Labs’ pharmacogenomic testing. We apply the science of molecular genetic testing to enhance your practice of personalized medicine. Pharmacogenomics enables physicians to identify the best treatment course for a patient as quickly as possible. 

With an understanding of each patient’s genetic profile, you can optimize drug selection and dosing. A one-time test gives you precision guidance for medications used in managing cardiovascular disease, mental disorders, pain, cancer, diabetes, gastrointestinal conditions, infectious disease, immune disorders, and urological conditions.

Many of the variations identified by pharmacogenomic testing center on the production of enzymes that metabolize drugs. Recommended medicine dosage is generally based on the metabolism of “extensive metabolizers.” Slow and intermediate metabolizers of a drug may experience more severe side effects and have a less effective therapeutic response. Ultrarapid metabolizers may metabolize the drug too quickly, making it difficult to maintain optimal drug levels in the body.

Pharmacogenomic testing uses genotyping to detect single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in several drug metabolizing enzyme (DME) genes. A physician can then utilize this information to select the most effective medicine and dosage for a patient to avoid adverse reactions.

LifeBrite Laboratories’ Pharmacogenomics Testing Includes:

Anti-Cancer Medications Panel

Drug Class Drugs Gene(s) Tested
Antifolates Methotrexate MTHFR
Detoxifying Agents Rasburicase G6PD
Protein Kinase Inhibitors Gefitinib, Dabrafenib CYP2D6, G6PD

 

Cardiovascular Medications Panel

Drug Class Drugs Gene(s) Tested
Angiotensin II Receptor Antagonists Azilsartan, Irbesartan, Losartan CYP2C9
Antianginal Agents Ranolazine CYP2D6
Antiarrhythmics Flecainide, Mexiletine Propafenone CYP2D6
Anticoagulants Warfarin VKORC1, CYP2C9
Antiplatelets Clopidogrel, Prasugrel CYP2C19
Beta Blockers Carvedilol, Metoprolol, Nebivolol, Propranolol, Timolol CYP2D6
Diuretics Torsemide CYP2C9
Statins Atorvastatin, Fluvastatin, Lovastatin, Pitavastatin, Pravastatin, Rosuvastatin, Simvastatin CYP2C9, CYP3A4, SLCO1B1

 

Diabetes and Gastrointestinal Medications Panel

Drug Class Drugs Gene(s) Tested
Meglitinides Repaglinide, Nategliniden CYP2C9, SLCO1B1
Sulfonylureas Chlorpropamide, Glimepiride, Glipizide, Glyburide, Tolbutamide CYP2C9
Antiemetics Dolasetron, Dronabinol, Metoclopramide, Netupitant-Palonosetron, Ondansetron, Palonosetron CYP2C9, CYP2D6
Proton Pump Inhibitors Dexlansoprazole, Esomeprazole, Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole CYP2C19
Gaucher Disease Eliglustat CYP2D6

 

Immunology and Urology Medications Panel

Drug Class Drugs Gene(s) Tested
Anti-gout Agents Lesinurad, Pegloticase, Probenecid CYP2C9, G6PD
Immunomodulators Leflunomide, Tofacitinib CYP2C19
Cholinergic Agonists Cevimeline CYP2D6
Immunosuppressant Tacrolimus CYP3A5
Alpha-Blockers for Benign Prostatic Tamsulosin CYP2D6
Antispasmodics for Overactive Bladder Darifenacin, Fesoterodine, Mirabegron, Tolterodine CYP2D6

 

Infectious Disease Medications Panel

Drug Class Drugs Gene(s) Tested
Antibiotics Dapsone, Methylene blue, Nitrofurantoin, Sulfamethoxazole G6PD
Anti-HIV Efavirenz CYP2B6
Antifungals Voriconazole CYP2C19
Antimalarials Proguanil, Chloroquine, Primaquine CYP2C19, G6PD

 

Pain Medications Panel

Drug Class Drugs Gene(s) Tested
Muscle Relaxants Tizanidine, Carisoprodol CYP1A2, CYP2C19
Anesthetic Propofol CYP2B6
NSAIDs Celecoxib, Diclofenac, Flurbiprofen, Ibuprofen, Indomethacin, Meloxicam, Piroxicam CYP2C9
Opioids Morphine, Methadone, Codeine, Dihydrocodeine, Hydrocodone, Oxycodone, Tramadol3, Fentanyl COMT, CYP2B6, CYP2D6, OPRM1

 

Psychotropic Medications Panel

Drug Class Drugs Gene(s) Tested
Antiaddictives Bupropion, Methadone, Naltrexone ANKK1, CYP2B6, OPRM1
Anti-ADHD Agents Dexmethylphenidate, Methylphenidate, Amphetamine, Dextroamphetamine, Lisdexamfetamine, Atomoxetine1, Clonidine ADRA2A, COMT, CYP2D6
Anticonvulsants Brivaracetam, Lacosamide, Phenobarbital, Primidone, Zonisamide, Fosphenytoin, Phenytoin CYP2C19, CYP2C9
Antidementia Agents Donepezil, Galantamine CYP2D6
Antidepressants Amitriptyline, Amoxapine, Bupropion, Citalopram, Clomipramine, Desipramine, Desvenlafaxine, Doxepin, Duloxetine, Escitalopram, Fluoxetine, Fluvoxamine, Imipramine, Maprotiline, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Protriptyline, Sertraline, Trimipramine, Venlafaxine Vortioxetine ANKK1, CYP2B6, CYP2C19, CYP2D6, HTR2A
Antipsychotics Aripiprazole, Brexpiprazole, Chlorpromazine, Clozapine, Fluphenazine, Haloperidol, Iloperidone, Olanzapine, Paliperidone, Perphenazine, Pimozide, Risperidone, Tetrabenazine, Thioridazine CYP1A2, CYP2D6, HTR2A
Benzodiazepines Clobazam, Diazepam, Lorazepam, Oxazepam CYP2C19, UGT2B15
Other Neurological Agents Dextromethorphan, Flibanserin CYP2C19, CYP2D6

 

Condition Gene Tested
Antipsychotic-Induced Hyperprolactinemia, tardive dyskinesia and weight gain ANKK1
Hyperhomocysteinemia MTHFR